Resveratrol Research: Recent Resveratrol Studies

As you know, resveratrol has been the subject of many television programs, newspapers and the popular media.

This includes 60 Minutes, Oprah, CBS News, ABC News and The New York Times.

But what about the research studies that have emerged on resveratrol?

Here's a collection of some of the recent resveratrol research that has been published.

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Being a newly discovered compound, there has also been many cell culture, in vitro and vivo studies done.

A well, human trials are underway, headed by Dr David Sinclair of Harvard, on the effect of resveratrol and a more potent version of resveratrol on cancer patients.

Recent studies and resveratrol research include:

Alzheimers

Anekonda TS, Reddy PH., Neuronal protection by sirtuins in Alzheimer's disease. J Neurochem. 2006 Jan;96(2):305-13. Epub 2005 Oct 7.

This study looked at the role of resveratrol in possible protection against Alzheimer's disease.

The study introduces the fact that the idea of resveratrol in the role of possibly preventing Alzheimers disease came from studies where:

"Caloric restriction and antioxidant treatments have shown useful effects in mouse models of aging and Alzheimer's disease (AD) and in limited human AD clinical trials."

The study here looked at the "possible mechanisms of sirtuins involved in neuronal protection and the potential therapeutic value of sirtuins in healthy aging and AD."

It seems that diseases of aging, as well as aging itself, may have links to the Sirtuin genes, calorie restriction, and possibly resveratrol.

Mice Studies

News Release From Harvard Medical School: Small Molecule Increases Lifespan and "Healthspan" of Obese Mice.

http://web.med.harvard.edu/sites/RELEASES/html/11_1Sinclair.html

The famous news release from the Harvard Medical School which created a big stir in the world of anti aging and anti aging supplements.

In this landmark research, Dr David SInclair showed the effects of resveratrol on mice, namely:

1. Cut in risk of death by 31%

2. In obese mice, reversed most of the biochemical and physical changes associated with a high calorie diet

3. Seem to mimic the effects of a calorie restriction diet without exercise

4. Reduced glucose and insulin levels and increased insulin sensitvity

David Sinclair is a researcher into anti aging, the Sirtuin genes ans resveratrol.

Cardioprotection

Penumathsa SV, Maulik N. Resveratrol: a promising agent in promoting cardioprotection against coronary heart disease. Can J Physiol Pharmacol. 2009 Apr;87(4):275-86.

This review article published on April 2009, discusses the ways that resveratrol may offer cardioprotection in relation to "myocardial infarction, hypercholesterolemia, and diabetes rendering its beneficial effects during health and disease."

The study mentioned the recent findings of the possible relationship between resveratrol and the risk factors that cause heart and coronary disease:

"We have recently reported the angiogenic, antihypercholesterolemic, and antidiabetic effects of resveratrol and the mechanisms involved in reduced ventricular remodeling and increased cardiac functions. We have also shown different strategic target molecules involved in resveratrol-mediated cardioprotection."

This review paper is suggesting that resveratrol has a role not only moderating the risk factors such as hyperlipidemia and diabetes, but also in the amount of cardiac damage itself.

Tumor metastases

Anticancer Res. 2009 Jan;29(1):355-62. Resveratrol inhibits tumor cell adhesion to endothelial cells by blocking ICAM-1 expression. Park JS, Kim KM, et al.

When cancer cells adhere to endothelial cells (blood vessel cells), it represents an importnat stage in cancer spread.

This study published in January 2009 looked at the effect of resveratrol on reducing this adhesion.

It was found that "Resveratrol inhibited PMA-induced HT1080 cells adhesion in a dose-dependent manner."

There are other studies on resveratrol and its anti cancer activity in cell culture and in vitro studies.

Human studies will be required to confirm the effect of resveratrol in humans.

To read more about studies of resveratrol, here are some resouces for research into resveratrol:

Here's the study on weight loss and reduced aging in mice:

http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0002264

Here's one on health and survival of mice with resveratrol:

http://www.nature.com/nature/journal/v444/n7117/abs/nature05354.html

How the Harvard Medical School promoted a product aimed at heart health and reduction of heart disease that contains resveratrol:

http://www.bio-medicine.org/medicine-news-1/Physician-Develops-Resveratrol-Evidence-Based-Nutraceutical-for-Heart-Health-36965-1/

A study on the biochemical mechanisms of this red wine grape antioxidant and eye health:

http://www.ncbi.nlm.nih.gov/pubmed/17724212

A study published in February 2009 looking at curcumin and resveratrol in reducing prostate cancer in mice:

http://www.ncbi.nlm.nih.gov/pubmed/19326431

These are just a sample of interesting and authoritative research papers and commentary on resveratrol scientific research and medical studies on popyphenols and antioxidants found in red grapes and red wine.

While the ideal resveratrol dosage is not yet agreed upon, and without many studies in humans, there are many case study and anecdotal evidence of benefits of resveratrol grape extract by men and women.

As you can see, there are vitro studies, animal studies, and human studies including case studies and clinical trials (randomised double blind trials) on a range of diseases of aging including cancers including skin, colon, prostate and breast cancer.

As an anti aging supplement, resveratrol extract has a wide ranging spectum of potential health effects.

As mentioned, it seems to act via the Sirtuin genes and affects aging as well as diseases associated with aging.

The resveratrol content is higher in seeded red grapes and red wine, and resveratrol supplements are the most popular way to get an adequate dose of resveratrol.

Resveratrol capsules and supplements enable you to have the benefits of red wine without the alcohol content that many people prefer to not have or cannot tolerate.

More and more people are interested in maintaining and improving health naturally and effectively, they are turning to antural antioxidants and the wisdom of nature to achieve better health, energy, weight control and wellbeing.

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